Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice
نویسندگان
چکیده
منابع مشابه
Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice
The melanocortin-4 receptor (MC4-R) is a G protein-coupled, seven-transmembrane receptor expressed in the brain. Inactivation of this receptor by gene targeting results in mice that develop a maturity onset obesity syndrome associated with hyperphagia, hyperinsulinemia, and hyperglycemia. This syndrome recapitulates several of the characteristic features of the agouti obesity syndrome, which re...
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ژورنال
عنوان ژورنال: Cell
سال: 1997
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)81865-6